Investigator clinical trials: How can we ask the question?

The development of knowledge about a treatment requires clinical trials. In addition to the trials initiated by the industry, some trials called Investigator initiated trials (it is) are developed on the initiative of the investigator. The assay must provide answers to one or several questions concerning the drug studied, so it is essential to determine the exact form of the question. Through three examples of drug development in the field of haemorrhagic diseases, we try to identify the difficulties encountered in developing these trials and the risks of misinterpretation of the results of these trials.