Short duration of post-amputation antibiotic therapy in diabetic foot patients with total resection of osteomyelitis

•We evaluated the long-term effectiveness of short-duration post-amputation antibiotic therapy in diabetic patients with total resection of osteomyelitis assessed by sterile bone bacteriological samples obtained from resection margins.•The endpoint was the absence of osteomyelitis relapse at 6 months, defined as recurrence of osteomyelitis with the need for surgical revision and/or new bone antibiotic therapy.•Of the 15 patients included in our study, 80% were cured without recurrence of osteomyelitis at 6 months, with a mean duration of post-surgical antibiotic therapy of 8.3±5.9 days.•In a small, real-life population, we showed that a short duration of post-amputation antibiotic therapy in diabetic patients is effective.