Co-occurrence of targetable mutations in Non-small cell lung cancer (NSCLC) patients harboring MAP2K1 mutations

Matthias Scheffler,Alessandra Holzem,Anna Kron,Lucia Nogova,Michaela A. Ihle,Cornelia von Levetzow,Jana Fassunke,Claudia Wömpner,Elisabeth Bitter,Sophia Koleczko,Diana S.Y. Abdulla,Sebastian Michels,Rieke Fischer,Richard Riedel, Jan-Philipp Weber,Theresa Westphal,Ulrich Gerigk,Jens Kern,Britta Kaminsky,Winfried Randerath

Lung Cancer（2020）

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摘要

•MAP2K1 mutations are rare genomic events in NSCLC.•They occur in both adenocarcinoma and squamous-cell carcinoma histology.•They are rarely exclusive, co-occurring with potentially targetable coaberrations.•Comprehensive multiplex sequencing at baseline is needed for detection.•Further analyses will investigate the use of MEK-inhibitors in these patients.

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关键词

Non-small cell lung cancer,MAP2K1,mutations,therapeutic options

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