Oncolytic vesicular stomatitis viruses selectively target M2 macrophages.

Megan Polzin,Jessica McCanless, Sylas Owen, Dalton Sizemore, Emily Lucero, Rebecca Fuller,Howard S Neufeld,Darren F Seals,Maryam Ahmed

Virus Research（2020）

引用 6|浏览5

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摘要

•Oncolytic vesicular stomatitis virus (VSV) modulates pro-tumor M2 macrophages.•M2 macrophages are susceptible to infection and killing by VSV.•The rM51R-M strain of VSV induces pro-inflammatory factors in M2 macrophages.•Wild-type rwt virus inhibits the development of invasive macrophage podosomes.

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关键词

Vesicular stomatitis virus,Macrophages,Matrix protein,Oncolytic agent,Podosomes

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