Blood-based analysis of 84 microRNAs identifies molecules deregulated in individuals with type-2 diabetes, risk factors for the disease or metabolic syndrome.

Margaritis Avgeris,Ioanna Kokkinopoulou,Eirini Maratou,Panayota Mitrou,Eleni Boutati,Andreas Scorilas,Emmanuel G Fragoulis,Maria-Ioanna Christodoulou

Diabetes Research and Clinical Practice（2020）

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摘要

Blood levels of miR-214-3p, miR-24-3p and let-7f-5p are down-regulated in T2D- and Met-S/T2D-RF subjects. Future studies are needed to evaluate their potential as disease biomarkers and elucidate the associated tissue-specific pathogenetic mechanisms.

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关键词

Type-2 diabetes,miRNAs,Insulin-pathway,Peripheral blood,RT-qPCR array

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