Co-exposure to multiple metals, TERT-CLPTM1L variants, and their joint influence on leukocyte telomere length.

Yansen Bai,Wenshan Fu,Xin Guan,Xiulong Wu,Guyanan Li,Wei Wei,Yue Feng,Hua Meng,Hang Li,Mengying Li,Ming Fu,Jiali Jie,Chenming Wang,Xiaomin Zhang,Meian He,Huan Guo

Environment International（2020）

引用 21|浏览42

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摘要

•Increased plasma manganese level is positively associated with telomere length.•Multipollutant associations suggest manganese as a sole predictor for telomere length.•Manganese has joint effects with TERT-CLPTM1L variants on increasing telomere length.•This study offered clues for the early prevention of telomere shortening related diseases.

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关键词

Telomere length,Multiple metals,TERT-CLPTM1L,Genetic variants

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