A Targetable Cue In T-Cell Malignancy
BLOOD(2020)
摘要
In this issue of Blood, De Smedt et al demonstrate that glucocorticoid treatment of a subset of T-cell acute lymphoblastic leukemia/T-cell acute lymphoblastic lymphoma (T-ALL/T-LBL) cells upregulates PIM1 expression, creating a synergistic vulnerability and potent antileukemic effect with PIM1 inhibitors in a preclinical model.(1)
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