PHF23 negatively regulates the autophagy of chondrocytes in osteoarthritis

Talatibaike Maimaitijuma,Jia-Hong Yu,Ya-Li Ren,Xin Yang,Heng Liu,Zhi-Chao Meng,Rui Wang,Yun-Peng Cui,Hao Wu,Li-Ping Pan,Yang Jiao,Ying-Yu Chen,Yong-Ping Cao

Life Sciences（2020）

引用 10|浏览57

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摘要

•PHF23 inhibits autophagy and mitophagy in IL-1β induced osteoarthritis chondrocytes.•Knockdown of PHF23 protects chondrocytes from IL-1β induced osteoarthritis by enhancing autophagy.•PHF23 alters the activities of AMPK and mTOR/S6K in osteoarthritis chondrocytes.

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关键词

PHF23,Autophagy,Mitophagy,Osteoarthritis,mTOR/S6K,AMPK

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