Synthesis of Tetranor-Pge1: A Urinary Metabolite of Prostaglandins E1 and E2
Tetrahedron letters(2020)
摘要
Prostaglandin E2 is produced in response to inflammation, often associated with human disease. As prostaglandins are rapidly metabolized, quantification of end urinary metabolites depend on chemical synthesis of isotopically labeled standards to support metabolite quantification. A concise synthesis of tetranor-PGE1 is described including a late stage incorporation of an isotopically labeled side-chain.
更多查看译文
关键词
Total synthesis,Prostaglandins,Synthesis strategy,Heck reaction
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要