Development of a highly sensitive chemiluminescence immunoassay for quantification of aggrecanase-generated ARGS aggrecan fragments in serum

Yi He, Kamilla E. Jensen,Anne Sofie Siebuhr,Morten A. Karsdal,Jonathan Larkin,Anne C. Bay-Jensen

Osteoarthritis and Cartilage（2021）

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摘要

The huARGS shows good technical performance and low biological variation. It has the potential to aid drug development in various stages, both as a PD biomarker and identifying progressors who might be likely to respond to an OA drug.

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关键词

Aggrecan,ADAMTS-5,Immunoassay,ARGS,Knee osteoarthritis

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