Impaired amyloid beta clearance and brain microvascular dysfunction are present in the Tg-SwDI mouse model of Alzheimer's disease.

Hector Rosas-Hernandez,Elvis Cuevas,James B Raymick,Bonnie L Robinson,Sumit Sarkar

Neuroscience（2020）

引用 7|浏览15

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摘要

•Tg-SwDI mice accumulate Aβ aggregates in their brain microvessels.•Tg-SwDI mice’s microvessels have decreased levels of P-gp and increased RAGE levels.•Tg-SwDI mice’s microvessels present lower levels of occludin.•Tg-SwDI mice’s brain endothelial cells present increased paracellular permeability.

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关键词

AD,Aβ,BBB,BMVECs,CAA,NFTs,RAGE,TJs,WT

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