Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers.

Priscila Longhin Bosquesi, Aylime Castanho Bolognesi Melchior,Aline Renata Pavan,Carolina Lanaro, Cristiane Maria de Souza,Radda Rusinova,Rafael Consolin Chelucci,Karina Pereira Barbieri,Guilherme Felipe Dos Santos Fernandes,Iracilda Zepone Carlos,Olaf Sparre Andersen,Fernando Ferreira Costa,Jean Leandro Dos Santos

Bioorganic Chemistry（2020）

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摘要

•New resveratrol derivatives (10a-i) with NO-donor properties.•All compounds exhibited in vivo analgesic effect.•All compounds did not induce membrane perturbation.•Compound 10a inhibited the production of the pro-inflammatory TNF-α and it was not mutagenic in the in vivo assay.•Compound 10a induced production of the gamma-globin chains (γG + γA) in CD34+ cells.

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关键词

Epigenetic,Fetal hemoglobin inducers,Gamma-globin inducers,Nitric oxide,Resveratrol,Sickle Cell Disease

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