NK Cell Receptor NKG2D Enforces Proinflammatory Features and Pathogenicity of Th1 and Th17 Cells

Marina Babic,Christoforos Dimitropoulos,Quirin Hammer,Christina Stehle,Frederik Heinrich, Assel Sarsenbayeva,Almut Eisele,Pawel Durek,Mir-Farzin Mashreghi,Berislav Lisnic,Jacques Van Snick,Max Lohning,Simon Fillatreau,David R. Withers,Nicola Gagliani,Samuel Huber,Richard A. Flavell,Bojan Polic,Chiara Romagnani

The Journal of experimental medicine/The journal of experimental medicine（2020）

引用 25|浏览66

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摘要

NKG2D is a danger sensor expressed on different subsets of innate and adaptive lymphocytes. This study demonstrates how NKG2D enforces proinflammatory features of Th1 and Th17 cells and promotes inflammation in vivo, identifying NKG2D as an important target for the amelioration of Th1/ Th17-mediated inflammatory diseases.

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