The impact of Dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression.

Chunmei Geng,Guoxian Hao,Qiao Yi,Yujin Guo,Dan Chen,Wenxiu Han,Jun Zhang,Mengqi Yang,Pei Jiang

Prostaglandins & Other Lipid Mediators（2020）

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摘要

•Our study is the first study to report changes in hippocampus lipids following NBP treatment in the LPS-induced rat model of depression.•Our lipidomic analysis provided important lipid biomarker candidates for depression and the NBP involvement in depression.•Our study demonstrated that most of the differentially expressed lipid metabolites were involved in four metabolic pathways.

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AA,AD,CAD,Cer,CI,CNS,CRP,CSF,DG,FST,GPCRs,GPI,HESI-II,HETE,HDL-c,HPA,IFN-γ,IL-1β,IL-6,IS,LDL-c,LPC,LPE,LPS,MG,MS,mRNA,NBP,OPLS-DA,PC,PCA,PE,PFC,PG,PI,PLS-DA,PS,SD,SMD,S/N,SPT,TCH,TG,TST,TNF-α,UPLC-MS,VIP

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