Rationale Of A Loading Dose Initiation For Hydroxychloroquine Treatment In Covid-19 Infection In The Discovery Trial-Authors' Response

Around the world, several dose regimens of hydroxychloroquine have been used for COVID-19 infection treatment, with the objective of identifying a short-term course. Hydroxychloroquine was found to decrease the viral replication in a concentration-dependent manner in vitro and to be more active when added prior to the viral challenge. A loading dose is used to rapidly attain a target drug concentration, which is usually considered as approximately the steady-state concentration. With a loading dose, the minimum effective concentration is reached much more rapidly than when using only the maintenance dose from the start. Thus, we propose a hydroxychloroquine sulphate dose regimen of 400mg twice daily at Day 1 then 400mg once daily from Day 2 to Day 10. We aimto evaluate this in the C-20-15 DisCoVeRy trial.