Metformin protects from oxaliplatin induced peripheral neuropathy in rats.
Neurobiology of Pain(2020)
摘要
•After oxaliplatin treatment rats developed mechanical and cold hyperalgesia.•We observed intraepidermal nerve fiber degeneration, and mild spinal cord gliosis.•Co treatment with Metformin could prevent all these pathological outcomes.•This suggests metformin as a candidate drug to prevent oxaliplatin-induced neuropathy.
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关键词
Oxaliplatin,Metformin,Peripheral neuropathy
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