Association between changes in gestational blood pressure and vanadium exposure in China.

OBJECTIVE:To investigate the association between urinary vanadium concentrations and blood pressure (BP) changes in Chinese pregnant women. METHODS:This longitudinal study included 716 pregnant women who visited our hospital in Wuhan, China, from 2014 to 2016. Urinary sample collection and BP measurements were performed at 9-15, 21-27, and 34-40 weeks of gestation. Outcomes were repeated BP measurements (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], and mean arterial pressure [MAP]) during pregnancy. RESULTS:The geometric mean of urinary vanadium concentrations was 0.65 μg/g creatinine. After adjusting for potential confounders, each threefold increase in urinary vanadium concentration was observed to be associated with a 1.06 mmHg decrease in SBP (95 % confidence interval [CI]: -1.80, -0.32), a 0.68 mmHg decrease in DBP (95 % CI: -1.32, -0.04), and a 0.81 mmHg decrease in MAP (95 % CI: -1.42, -0.19). Cross-sectional analysis showed a negative association between urinary vanadium concentrations and BP in the third trimester. Specifically, each threefold increase in urinary vanadium concentration in the second trimester was associated with decreases in SBP, DBP, PP, and MAP by 2.72 mmHg (95 % CI: -4.02, -1.41), 1.57 mmHg (95 % CI: -2.72, -0.42), 1.14 mmHg (95 % CI: -2.15, -0.14), and 1.95 mmHg (95 % CI: -3.06, -0.85), respectively, in the third trimester. CONCLUSION:To the best of our knowledge, this is the first longitudinal study that suggests the negative association between vanadium exposure and BP among pregnant women in China.