Antidementia effects of Enterococcus faecalis 2001 are associated with enhancement of hippocampal neurogenesis via the ERK-CREB-BDNF pathway in olfactory bulbectomized mice.

Kohei Takahashi,Kazuhiro Kurokawa,Kazuya Miyagawa,Atsumi Mochida-Saito,Yukio Nemoto,Hiroyuki Iwasa,Osamu Nakagawasai,Takeshi Tadano,Hiroshi Takeda,Minoru Tsuji

Physiology & Behavior（2020）

引用 16|浏览23

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摘要

•EF-2001 prevented cognitive dysfunction in OBX mice.•EF-2001 enhanced the hippocampal p-ERK1/2, p-CREB, BDNF, and DCX levels in OBX mice.•EF-2001 prevented the reduction of neurogenesis in the hippocampal dentate gyrus of OBX mice.•EF-2001 has the potential to prevent cognitive dysfunctions in neuropsychiatric disorders.

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关键词

Antidementia effect,Brain-derived neurotrophic factor,EF-2001,Hippocampus,Neurogenesis,Olfactory bulbectomy

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