1 H NMR-based metabolomics analyses in children with Helicobacter pylori infection and the alteration of serum metabolites after treatment.

•This is the first study using 1H NMR-based metabolomics approach to explore the effects of H. pylori infection in children.•Various metabolite alterations might play an important role in the pathogenesis of H. pylori infection in children.•The disturbances in metabolism could be recovered in H. pylori-infected children after eradication therapies.•TMAO and lactate might be useful as biomarkers for evaluating the success of H. pylori eradication therapies.