Hypolipidemic and anti-inflammatory properties of phenolic richButia odoratafruit extract: potential involvement of paraoxonase activity

Aim:This study investigated the effects of polarButia odoratafruit extract on metabolic, inflammatory, and oxidative stress parameters in rats submitted to a hyperlipidaemia condition induced by tyloxapol. Methods:Animals were divided into 3 groups: saline, saline plus tyloxapol, andB. odorataextract plus tyloxapol. Animals were treated for 15 days with a saline solution orB. odoratafruit extract and after hyperlipidaemia was induced by tyloxapol. Results:Treatment withB. odorataextract reduced serum triglyceride, total cholesterol, C-reactive protein, and adenosine deaminase and butyrylcholinesterase activities when compared to the tyloxapol group. HDL-cholesterol and paraoxonase 1 activity were higher inB. odorataextract treated animals when compared to tyloxapol-treated animals. No differences were observed in hepatic oxidative stress parameters. Phenolic compounds present inB. odoratafruit extract were identified and quantified by LC-MS/MS. Conclusion:These findings indicated that phenolic richB. odorataextract has hypolipidemic and anti-inflammatory effects in hyperlipidemic rats.