Floxuridine-chlorambucil conjugate nanodrugs for ovarian cancer combination chemotherapy.

Ping Huang,Guanchun Wang,Zhaohong Wang,Cancan Zhang,Fengmian Wang,Xiaoxiao Cui, Sini Guo,Wei Huang,Rong Zhang,Deyue Yan

Colloids and Surfaces B: Biointerfaces（2020）

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摘要

•Carrier-free nanodrugs are prepared from amphiphilic Fud-Cb conjugates.•Carrier-free nanodrugs are used for ovarian cancer combination therapy firstly.•Carrier-free nanodrugs can release free Fud and Cb in ovarian cancer cells.•Carrier-free nanodrugs exhibit synergistic therapeutic effects on ovarian cancer cells.

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关键词

Self-Assembly,Nanodrugs,Combination chemotherapy,Floxuridine-chlorambucil conjugate,Ovarian cancer

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