Cellular toxicological characterization of a thioxolated arsenic-containing hydrocarbon.

Franziska Ebert, Vanessa Ziemann,Viktoria Klara Wandt,Barbara Witt,Sandra Marie Müller,Nikolaus Guttenberger,Ezgi Eyluel Bankoglu,Helga Stopper,Georg Raber,Kevin A Francesconi,Tanja Schwerdtle

Journal of Trace Elements in Medicine and Biology（2020）

引用 6|浏览27

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摘要

•Thioxo-AsHC 348 is substantially cytotoxic in cultured human liver cells.•Cellular bioavailability of thioxo-AsHC 348 was 10 times lower than for oxo-AsHC 332.•Thioxo-AsHC 348 neither increased cellular oxidative stress nor caused DNA lesions.

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关键词

Aa,AsHC,Carboxy-DCFH-DA,DHE,iAsIII,LDH,MMS,TBH

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