Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts

Aurélien Pélissier
Aurélien Pélissier
Youcef Akrout
Youcef Akrout
Katharina Jahn
Katharina Jahn
Ulf Klein
Ulf Klein

CELLS, pp. 14482020.

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Abstract:

Germinal centers (GCs) are specialized compartments within the secondary lymphoid organs where B cells proliferate, differentiate, and mutate their antibody genes in response to the presence of foreign antigens. Through the GC lifespan, interclonal competition between B cells leads to increased affinity of the B cell receptors for antigen...More

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