Neuropeptide Y3-36 incorporated into PVAX nanoparticle improves angiogenesis in a murine model of myocardial ischemia

Eitezaz Mahmood,Soochan Bae,Omar Chaudhary,Ruby Feng,Feroze Mahmood,Simon Robson,Dongwon Lee,Peter M. Kang,Robina Matyal

European Journal of Pharmacology（2020）

引用 4|浏览34

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摘要

Neuropeptide-Y (NPY) leads to angiogenesis and remodeling of the ischemic myocardium. The objective of this study is to assess the therapeutic potential of NPY in a model of acute myocardial ischemia using a nanoparticles delivery system targeted to tissue with oxidative stress.

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关键词

Neurotransmitter,Neuropeptide Y,Microvascular disease,Nanoparticles,Diabetes,Myocardial ischemia

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