Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration

Peter U. Hámor,Mariola J. Edelmann,Christina Gobin,Marek Schwendt

Neuroscience（2020）

引用 5|浏览4

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摘要

•Cocaine self-administration and prolonged abstinence alter global protein expression in the central amygdala.•Tyrosine hydroxylase is the most upregulated, while contactin-1 is one of the most downregulated proteins.•Protein networks linked to neurobehavioral disorders, energy metabolism, and plasticity are the most significantly altered.

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关键词

addiction,cocaine self-administration,central nucleus of the amygdala,proteomic analysis,tyrosine hydroxylase,contactin-1

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