Identification of rare variants in CADM1 in patients with anorexia nervosa.

•A large GWAS meta-analysis identified a significant intronic SNP (rs6589488) as associated with anorexia nervosa (AN).•rs6589488 might have gotten its informativity as being in linkage disequilibrium with close but unknown functional variants.•Screening of the CADM1 gene in a selective cohort of AN individuals identified 12 different single nucleotide polymorphisms, not deleterious.•The initial variant appears to be not associated with causative coding variant in the vicinity.•The intronic variant in CADM1 could be in linkage disequilibrium with other causative variants located in NNMT.