Toxicokinetics of the plasticizer, N-butylbenzenesulfonamide, in plasma and brain following oral exposure in rodents: Route, species, and sex comparison.

Suramya Waidyanatha,Seth Gibbs,Natalie South,Jeremy P Smith,Esra Mutlu,Brian Burback,Yu Cao,Cynthia V Rider

Toxicology Reports（2020）

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摘要

•The kinetics of N-butylbenzenesulfonamide (NBBS) was investigated in rodents.•NBBS was rapidly absorbed following gavage exposure in rodents.•It was rapidly eliminated with a half-life ≤3.5 h.•Bioavailability following gavage administration was high.•Systemic exposure was higher following gavage exposure than following via feed.

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N-butylbenzenesulfonamide,plasticizer,systemic exposure,half-life,clearance,rodents

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