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    • Inverse Probability of Treatment Analysis of Open Vs Endovascular Repair in Ruptured Infrarenal Aortic Aneurysm – Cohort Study

    Wolf Eilenberg,Michael Schwarz,Maria Schoder,Markus Klinger,Christian Kinstner,Josif Nanobachvili,Ihor Huk,Christoph Neumayer,Georg Heinze,Christoph M. Domenig

    International Journal of Surgery（2020）SCI 3区

    Med Univ Vienna | Dept Biomed Imaging & Image Guided Therapy

    Cited 0|Views24
    Abstract
    Background: To compare open repair (OR) with EVAR for the management of ruptured infrarenal abdominal aortic aneurysms (RAAA) in a cohort study over a time period of 15 years with inverse probability of treatment weights. Material and methods: From 2000/01 through 2015/12 136 patients were treated for RAAA, 98 (72.1%) underwent OR, 38 (27.9%) were treated with EVAR. Thirty-day and long-term mortality (survival) were analyzed in this IRB-approved retrospective cohort study. Treatment modalities were compared using inverse probability of treatment weights to adjust for imbalances in demographic data and risk factors. Results: EVAR patients were older (75.11 +/- 7.17 vs 69.79 +/- 10.24; p=0.001). There was no statistical difference in gender, hypertension, COPD, CAD, or diabetes. GFR was significantly higher in OR patients (71.4 +/- 31.09 vs. 53.68 +/- 25.73). Postoperative dialysis was required more frequently in EVAR patients: 11% vs. 2% (p = 0.099). In the OR group, adjusted cumulative survival was 70.4% (61.1, 81.1) at 30 days, 47.0% (37.1, 59.6) at one year and 38.3% (28.6, 51.3) at 5 years. In the EVAR group the corresponding numbers were 77.0% (67.7, 87.5), 67.5% (57.0, 80.0) and 41.7% (30.4, 57.4), respectively. Conclusion: There is evidence for EVAR patients exhibiting a benefit in one-year survival, while patients treated with OR may have more favorable long-term survival given they survive for at least one year. Herein we provide a statistically rigorous comparison of OR and EVAR in short and long-term outcomes with up to 15 years of follow-up.
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    Aortic aneurysm,Infrarenal,Ruptured,Open repair,EVAR,Propensity score
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    【要点】：本研究通过15年的队列研究，使用逆概率处理权重比较了开放修复（OR）与腔内修复（EVAR）治疗破裂腹主动脉瘤（RAAA）的短期和长期生存率，发现EVAR在一年生存率上有优势，而OR患者在至少存活一年后可能有更佳的长期生存率。
    

    【方法】：采用逆概率处理权重调整人口数据和风险因素的不平衡，对两种治疗方式的短期和长期生存率进行了比较。
    

    【实验】：在2000/01至2015/12期间共136名RAAA患者参与研究，其中98名（72.1%）接受OR治疗，38名（27.9%）接受EVAR治疗。通过逆概率处理权重分析得出，两组患者在30天、一年和五年生存率的差异。数据来源于经伦理委员会批准的回顾性队列研究。
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