Probing the recognition specificity of α V β 1 integrin and syndecan-4 using force spectroscopy.

Małgorzata Lekka,Katarzyna Herman,Joanna Zemła,Łukasz Bodek,Grażyna Pyka-Fościak,Dorota Gil,Joanna Dulińska-Litewka,Arkadiusz Ptak,Piotr Laidler

Micron（2020）

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摘要

•αV expression classifies bladder cancer cells into two groups.•Syndecan-4 (SDC4) expression was the largest in bladder cancer cells.•SMFS reveal various unbinding kinetics for SCD4-VN and αVβ1 –VN complexes.•Unbinding of αVβ1 from VN proceeds before the unbinding of SDC-4.

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关键词

Single molecule force spectroscopy,Specific recognition,Integrins,Syndecans,Vitronectin

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