Genetic Polymorphisms Of Superoxide Dismutase 1 Are Associated With The Serum Lipid Profiles Of Han Chinese Adults In A Sexually Dimorphic Manner

Inspired by the mechanistic correlations between superoxide dismutase 1 (SOD1) and lipid metabolism, the associations ofSOD1single nucleotide polymorphisms (SNPs) with circulating lipid levels were explored. In 2621 Chinese Han adults, randomly recruited from a health examination center without organic diseases, cancers, and pregnancy, three tag SNPs, rs4998557, rs1041740, and rs17880487 selected by Haploview software were genotyped with a probe-based real-time quantitative PCR method. In both genders, most parameters of the dyslipidemia adults were inferior (P< 0.001) to those of the non-dyslipidemia adults, and genotype frequencies of rs4998557 and rs17880487 were significantly different (P< 0.05) between the normal and abnormal subgroups of total cholesterol (TC) or high-density lipoprotein cholesterol (HDLC). Adjusted for confounding factors, logistic regression analyses revealed that in males rs4998557A, rs1041740T, and rs17880487T reduced the risk of high TC and/or LDLC (P< 0.05), and rs4998557A and rs17880487T increased the risk of low HDLC (P< 0.05); but in females, none of the SNPs had associations with any of the lipid parameters (P> 0.05). Conclusively, characterized by a sexual dimorphism, theSOD1polymorphisms were associated with the lipid disorders in the adult males but not females of the Chinese Han population.