Fampridine-induced changes in walking kinetics are associated with clinical improvements in patients with multiple sclerosis.
Journal of the Neurological Sciences(2020)
摘要
Gait dysfunction is common in patients with multiple sclerosis (PwMS). Treatment with prolonged-release fampridine (PR-fampridine) improves walking ability in some PwMS. Associated fampridine-induced changes in the walking pattern are still poorly understood but may provide a better understanding of the mechanisms underlying the beneficial drug effects.
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关键词
Fampridine,Dalfampridine,Multiple sclerosis,Gait,Walking pattern,Kinetics,Locomotor mechanisms
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