Effect of crystallographic orientation on atom probe tomography geochemical data?

•The study of the crystal orientation effect is of importance for the interpretation of APT data.•APT bulk and isotopic mineral compositions are not affected by crystallographic orientation.•3D reconstructions are consistent for galena (100) and (001) planes and spinel (100) and (111) planes.•4. 2D density distribution maps do not vary significantly with the crystallographic orientation.