A randomized trial on the effect of oral combined estradiol and drospirenone on glucose and insulin metabolism in healthy menopausal women with a normal oral glucose tolerance test.

•This prospective, randomized, placebo-controlled study recruited 80 healthy postmenopausal women.•We observed a trend towards lower insulin levels in an oral glucose tolerance test among women taking menopausal hormone therapy.•The peak insulin levels in the women taking menopausal hormone therapy at the end of the study period were significantly lower than at baseline, with a non-significant trend towards a lower total area under the curve.•Menopausal hormone therapy increased glucose levels.