Modulation by chronic stress and ketamine of ionotropic AMPA/NMDA and metabotropic glutamate receptors in the rat hippocampus.

Mohammed E A Elhussiny,Giulia Carini,Jessica Mingardi, Paolo Tornese,Nathalie Sala,Federica Bono,Chiara Fiorentini,Luca La Via,Maurizio Popoli,Laura Musazzi,Alessandro Barbon

Progress in Neuro-Psychopharmacology and Biological Psychiatry（2021）

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摘要

Converging clinical and preclinical evidence has shown that dysfunction of the glutamate system is a core feature of major depressive disorder. In this context, the N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has raised growing interest as fast acting antidepressant.

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关键词

Chronic mild stress,Stress vulnerability,Ketamine,Antidepressant,Glutamate receptors,RNA editing

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