The homeobox protein Prox 1 is a negative modulator of ERR a / PGC-1 a bioenergetic functions

Goodman Cancer Centre, McGill University, Montréal, Québec H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3G 1Y6, Canada; Department of Systems Biology, Massachusetts General Hospital, Cambridge, Massachusetts 02142, USA; Centre for Human Genetic Research, Massachusetts General Hospital, Cambridge, Massachusetts 02142, USA; Broad Institute of Massachusetts Institute of Technology/Harvard, Cambridge, Massachusetts 02142, USA; Department of Medicine, McGill University, Montréal, Québec H3G 1Y6, Canada; Department of Oncology, McGill University, Montréal, Québec H3G 1Y6, Canada