Compendia of Public Gene Expression Data Discovery and Preclinical Validation of Drug Indications Using

therapies. and we now have a way to mine available data for fast routes to new disease −− inflammatory bowel disease lung cancer and −− drugs are therefore good candidates for recycling to treat two diseases in need of better therapies improved damage in colon tissue of rats treated with trinitrobenzenesulfonic acid, a model of the disease. These two mice. In addition, the antiepileptic topiramate, predicted to improve inflammatory bowel disease by similarity score, antiulcer drug, predicted by the authors to be effective against lung cancer, inhibited tumor cells in vitro and in vivo in in the ultimate test of method, the authors confirmed two new predictions in animal experiments: Cimetidine, an and other cancers (esophagus, lung, and colon), and there is experimental evidence that this is indeed the case. But histone deacetylase inhibitors trichostatin A, valproic acid, and vorinostat were predicted to work against brain tumors treatment for Crohn's disease and ulcerative colitis, showed a strong similarity score for these two diseases. The This proved to be true for a number of drugs already on the market. The corticosteroid prednisolone, a common therapy. 1 would predict that the drug would ameliorate the abnormalities in the disease and thus be an effective − score of 1 (exactly opposite signatures). The investigators suggested that a similarity − perfect correlation of signatures) to (a Technology. A similarity score calculated by the authors for every possible pair of drug and disease ranged from +1 treated with bioactive small molecules that is maintained at the Broad Institute at Massachusetts Institute of signatures for 164 drugs from the Connectivity Map, a collection of mRNA expression data from cultured human cells compared to normal individuals. They compared each of these disease signatures to each of the gene expression diseases, which they defined as the set of mRNAs that reliably increase or decrease in patients with that disease The authors scrutinized the data in Gene Expression Omnibus and identified a disease signature for 100 approach. this drug and an antiepileptic can be reused for lung cancer and inflammatory bowel disease reinforces the promise of drug-disease pairs and predict new indications for already approved agents. Experimental validation that an antiulcer and 164 drugs. By pairing drugs that correct abnormal gene expression in diseases, they confirm known effective . examined publicly available gene expression data and determined the genes affected in 100 diseases et al Dudley . and et al required by the Food and Drug Administration and other regulatory agencies. In a pair of papers, Sirota can speed their adoption in the clinic because they can often take advantage of the existing rigorous safety testing and for drug development too. Repurposing existing, approved drugs −− Recycling is good for the environment Greening Drug Discovery