Tau distribution in probable Cerebral Amyloid Angiopathy

Cerebrovascular deposition of amyloid-ß (cerebral amyloid angiopathy, CAA) is associated with magnetic resonance imaging findings of lobar hemorrhage, cerebral microbleeds, andor cortical superficial siderosis. Although pathological studies suggest that The aim was to evaluate the relationship between tau may co-localise with vascular amyloid, with relevance for understanding disease mechanisms, this has not yet been investigated in CAA in vivo. and tau in CAA patients. We therefore used Three patients with clinically diagnosed CAA underwent [C]Pittsburgh Compound B PET or [18F] Florbetaben PET to measure amyloid burden, and [F]T807 to measure paired helical filament tau in patients with probable CAA. The regions with that had cerebral microbleeds or cortical superficial siderosis largely overlapped with those showing regions that showed iincreased [F]T807 and uptake as well as increased [C]PiB uptake. Our study This provides preliminary in vivo evidence that vascular amyloid is associated with local production of paired helical filament tau.