Resveratrol inhibits the TRIF dependent pathway by up-regulating SARM,

1 contributing to anti-inflammatory effects after respiratory syncytial virus 2 infection 3 Running title: SARM regulated IFN-γ after RSV infection 4 Tiantian Liu , Na Zang, Na Zhou, Wei Li, Xiaohong Xie, Yu Deng, Luo Ren, 5 Xiaoru Long , Simin Li, Lili Zhou, Xiaodong Zhao, Wenwei Tu, Lijia Wang, 6 Bin Tan , Enmei Liu. 7 1 Ministry of Education Key Laboratory of Child Development and Disorders; Key 8 Laboratory of Pediatrics in Chongqing , CSTC2009CA5002; Chongqing 9 International Science and Technology Cooperation Center for Child Development 10 and Disorders, Chongqing Medical University, Chongqing 400014, China; 11 Department of Respiratory Medicine, Children's Hospital of Chongqing Medical 12 University, Chongqing, China. 13 3 Department of Immunology, Children's Hospital of Chongqing Medical University, 14 Chongqing, China. 15 Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of 16 Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China. 17 *These authors contributed equally to this work. 18 # Corresponding author. Mailing address: Department of Respiratory Medicine, 19 Children's Hospital of Chongqing Medical University, Chongqing, China, No.136, 20 Zhongshan 2nd Road, Yuzhong District, Chongqing, 400014, China, Telephone: 21 JVI Accepts, published online ahead of print on 29 January 2014 J. Virol. doi:10.1128/JVI.03637-13 Copyright © 2014, American Society for Microbiology. All Rights Reserved.