Biosynthesis of 2 ’-chloropentostatin and 2 ’-amino-2 ’-deoxyadenosine 1 highlights a single gene cluster performing two independent pathways 2 in Actinomadura sp . ATCC 39365 3

Biosynthesis of 2’-chloropentostatin and 2’-amino-2’-deoxyadenosine 1 highlights a single gene cluster performing two independent pathways 2 in Actinomadura sp. ATCC 39365 3 Yaojie Gao, Gudan Xu, Pan Wu, Jin Liu, You-sheng Cai, † Zixin Deng, Wenqing Chen 4 Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and 5 School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China 6 Co-first author 7 For Correspondence: Wenqing Chen, School of Pharmaceutical Sciences, Wuhan University, 8 Wuhan 430071, China. E-mail: wqchen@whu.edu.cn, Tel: +86-27-68756713, Fax: +86-279 68759850. 10