5-(Perylen-3-ylethynyl)uracil Derivatives Inhibit Reproduction of Respiratory Viruses

Y. V. Nikolayeva,E. A. Ulashchik, E. V. Chekerda, A. V. Galochkina, N. A. Slesarchuk, A. A. Chistov, T. D. Nikitin,V. A. Korshun,V. V. Shmanai,A. V. Ustinov,A. A. Shtro

Russian Journal of Bioorganic Chemistry（2020）

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摘要

In this work, we describe the synthesis of 5-(perylen-3-ylethynyl)uridine and its ability to effectively inhibit the replication of respiratory disease pathogens in cell culture, namely: influenza A virus (IVA); type 3 parainfluenza virus (PIV-3); and human respiratory syncytial virus (RSV). Related known compounds were also analyzed: 5-(perylen-3-ylethynyl)-2′-deoxy-uridine; 5-(perylen-3-ylethynyl)-arabino-uridine; and 1-carboxymethyl-3-pivaloyloxymethyl-5-(perylen-3-ylethynyl)uracil.

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关键词

perylenylethynyluracil compounds, nucleosides, non-nucleoside derivatives, antiviral activity, influenza A virus, respiratory viruses

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