Allosteric Inhibition of the IRE 1 a RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

Rajarshi Ghosh,1,2,5,6,7,12 Likun Wang,1,5,6,7,12 Eric S. Wang,2,12 B. Gayani K. Perera,8 Aeid Igbaria,1,5,6,7 Shuhei Morita,1,5,6,7 Kris Prado,1,5,6,7 Maike Thamsen,1,5,6,7 Deborah Caswell,2 Hector Macias,1,5 Kurt F. Weiberth,1,5,6,7 Micah J. Gliedt,1,6 Marcel V. Alavi,3 Sanjay B. Hari,8 Arinjay K. Mitra,8 Barun Bhhatarai,10 Stephan C. Schürer,9,10 Erik L. Snapp,11 Douglas B. Gould,3,4 Michael S. German,1,5 Bradley J. Backes,1,6 Dustin J. Maly,8 Scott A. Oakes,2,5,* and Feroz R. Papa1,5,6,7,* 1Department of Medicine 2Department of Pathology 3Department of Ophthalmology 4Department of Anatomy 5Diabetes Center 6Lung Biology Center 7California Institute for Quantitative Biosciences University of California, San Francisco, San Francisco, CA 94143, USA 8Department of Chemistry, University of Washington, Seattle, WA 98195, USA 9Center for Computational Science 10Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, FL 33136, USA 11Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA 12Co-first author *Correspondence: scott.oakes@ucsf.edu (S.A.O.), frpapa@medicine.ucsf.edu (F.R.P.) http://dx.doi.org/10.1016/j.cell.2014.07.002