Swapping nematode and virus resistance in potato 2 3 4 Sequence exchange between homologous NB-LRR genes converts virus resistance into 5 nematode resistance , and vice versa

1 Swapping nematode and virus resistance in potato 2 3 4 Sequence exchange between homologous NB-LRR genes converts virus resistance into 5 nematode resistance, and vice versa 6 7 Erik Slootweg 1 , Kamila Koropacka 1, $ , Jan Roosien 1 , Robert Dees 2, ± , Hein Overmars 1 , Rene 8 Klein Lankhorst 3 , Casper van Schaik 1 , Rikus Pomp 1 , Liesbeth Bouwman 1 , Johannes Helder 1 , 9 Arjen Schots 2 , Jaap Bakker 1 , Geert Smant 1 , Aska Goverse 1 10 11 1 Lab of Nematology and 2 Lab of Molecular Recognition and Antigen Technology, Dep. of 12 Plant Sciences, Wageningen University, 3 Plant Research International, Centre for 13 Biosystems Genomics, Droevendaalsesteeg 1, 6708 PD, Wageningen, the Netherlands. 14 15 16 17 One sentence summary 18 Domain swapping between the NB-LRR immune receptors Rx1 and Gpa2 converts extreme 19 resistance to potato virus X in the shoots into potato cyst nematode resistance in the roots, and 20 vice versa. 21 22 23 Plant Physiology Preview. Published on July 26, 2017, as DOI:10.1104/pp.17.00485