Gene Expression And Molecular Pathways Associated With Rapid Antidepressant Response To Ketamine In Patients With Treatment Resistant Depression

Ketamine is an NMDA receptor antagonist and glutamate modulator with rapid antidepressant effects in patients with treatment resistant depression (TRD). To gain insights into the etiopathology of TRD and ketamine’s mechanism of action, we examined gene expression profiles in patients compared to healthy controls (HC) and in patients before and after ketamine treatment.