Sec 22 regulates ER morphology but not autophagy and is required for eye development in Drosophila

The endoplasmic reticulum (ER) is a highly dynamic organelle that plays a critical role in many cellular processes. Abnormal ER morphology is associated with some human diseases, although little is known regarding how ER morphology is regulated. Using a forward genetic screen to identify genes that regulated ER morphology in Drosophila, we identified a mutant of Sec22, the orthologs of which in yeast, plants, and humans are required for ER to Golgi trafficking. However, the physiological function of Sec22 has not been previously investigated http://www.jbc.org/cgi/doi/10.1074/jbc.M115.640920 The latest version is at JBC Papers in Press. Published on February 10, 2015 as Manuscript M115.640920