Myocardial Infarction Persistent ST Segment Depression in Precordial Leads V 5 – V 6 After Q-Wave Anterior Wall Myocardial Infarction Is Associated With Restrictive Physiology of the Left Ventricle

METHODS We prospectively studied 19 patients after Q-wave anterior wall MI (.6 months). All patients underwent 12-lead ECG recording, symptom-limited treadmill exercise testing with single photon emission computed tomography thallium-201 imaging, transthoracic Doppler echocardiography, cardiac catheterization and measurement of circulating atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels. Patients were classified based on the presence of ST segment depression in leads V5–V6: Group I 5 ST segment depression ,0.1 mV (n 5 10); Group II 5 ST segment depression $0.1 mV (n 5 9).