’ s response to reviews Title : Urea Reduction Ratio May be a Simpler Approach for Measurement of Adequacy of Intermittent Hemodialysis in Acute Kidney Injury

Title: Urea Reduction Ratio May be a Simpler Approach for Measurement of Adequacy of Intermittent Hemodialysis in Acute Kidney Injury Authors: Kelly Liang (liangk@upmc.edu) Jane Zhang (Jane.Zhang@va.gov) Paul Palevsky (palevsky@pitt.edu) Version: 3 Date: 08 Feb 2019 Author’s response to reviews: Editor Comments: 1. Ethics approval and consent to participate Thank you for providing an ethics and consent to participate statement. Please ensure that the full names of IRBs at each of the participating study sites are included in this section as you mentioned. Please also include a consent to participate statement in this section, you may copy the relevant content from the Methods section. The full names of IRBs at each of the participating study sites have now been included in the “Ethics approval and consent to participate” section (p. 14). A consent to participate statement has been added to this section: “Written informed consent was obtained prior to enrollment and randomization of all participants.”