Presence ofMacroalbuminuria Predicts Severe Hypoglycemia in PatientsWith Type 2 DiabetesMellitus A 10-year follow-up study

RESEARCH DESIGN AND METHODSdFrom January 2000 to December 2002, patients with type 2 diabetes aged 25–75 years without chronic kidney disease (estimated glomerular filtration rate $60 mL/min/1.73 m) were consecutively recruited (n = 1,217) and followed-up in January 2011 and May 2012. Severe hypoglycemia (SH) was defined as an event requiring the assistance of another person to actively administer glucose, hospitalization, or medical care in an emergency department. We used Cox proportional hazard regression analysis to test the association between SH episodes and potential explanatory variables.