Mechanistic and pharmacological characterization of PF-04457845 : a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain

Pfizer Worldwide Research and Development, Groton, CT 06340, USA (K.A., Y.Z., C.S., D.S.J.); Ann Arbor, MI 48105, USA (K.A., S.E.S., M.B.L., D.B. N.S., D.T.D., Y.Z., S.S., K.V.B., S.N.B., C. S., D.S.J.); Cambridge, Massachusetts 63017, USA (D.B.); Sandwich, Kent, CT13 9NJ, UK (T.Y., P.W.); ActivX Biosciences, 11025 North Torrey Pines Road, La Jolla, CA 92037, USA (T.K.N.); and The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, CA 92037, USA (J.L.B., D.K.N., E.W., B.F.C.) JPET Fast Forward. Published on April 19, 2011 as DOI:10.1124/jpet.111.180257