ff ects in the evolution of dihydrofolate reductase †

Departament de Qúımica F́ısica i Anaĺıtic Spain. E-mail: moliner@uji.es School of Chemistry & Cardiff Catalysis Cardiff, CF10 3AT, UK. E-mail: allemannrk@ Departament de Qúımica F́ısica, Universit E-mail: ignacio.tunon@uv.es † Electronic supplementary information procedures; mass spectra of puried tabulated experimental data for kH, kcat, kH; methodological details of QM/MM ca and tunneling coefficients and quantu 10.1039/c5sc04209g ‡ These authors contribute equally. Cite this: Chem. Sci., 2016, 7, 3248