Investigating the role of residues W 228 and Y 233 in the structure and activity 1 of the GIM-1 metallo-β-lactamase 2

1 The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, Faculty of Science and 5 Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway. 2 Centre for Applied Biotechnology, 6 Uni Research AS, Thormøhlensgt. 55, N-5008 Bergen, Norway. 3 School of Cellular and Molecular Medicine, 7 Medical Science Building, University of Bristol, University Walk, Clifton, Bristol BS8 1TD, UK. 4 Norwegian 8 National Advisory Unit on Detection of Antimicrobial Resistance, Department of Microbiology and Infection 9 Control, University Hospital of North Norway (UNN), N-9038 Tromsø, Norway. 5 Department of Pharmacy, UiT 10 The Arctic University of Norway, N-9037 Tromsø, Norway. 11